Killian Hayes scored 25 points for Detroit, which has alternated wins and losses in its last seven games after a six-game losing streak.
“That’s a team playing for a championship and we shot ourselves in the foot,” Pistons coach Dwane Casey said. “We had 22 turnovers – the same number we had in the last game against them. We can’t give them points like that.”
Isaiah Stewart finished with 20 points and 13 rebounds, while Bojan Bogdanovic had 20 points.
“Stew is the heart of this team,” Casey said. “He’s not going to be perfect, but you know what you are going to get from him every night.”
The Sixers led 71-54 at halftime, thanks to Harrell’s 16 points and Harden’s 13 points, 10 rebounds and nine assists. Harden only needed 27 seconds in the second half to complete his triple-double, setting up Tobias Harris’ basket to put Philadelphia up by 19.
Maxey had 11 points in the third to help stay in control. The Sixers outscored the Pistons 29-28 in the quarter to take a 100-82 lead into the fourth.