Nation’s oldest hospital in Philadelphia will turn its original building into a museum to mark America’s 250th birthday
Pennsylvania Hospital, founded in 1751, treated patients in the Pine Building. The museum will feature the original surgical theater and other exhibits.
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Pharmacist Mildred Carlisle worked at Pennsylvania Hospital in the early 1900s. (Courtesy of Penn Medicine)
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More than two decades before the Declaration of Independence was signed in Philadelphia, notable figures like Benjamin Franklin and Dr. Thomas Bond opened the country’s first legally chartered hospital in the birthplace of the United States.
Now, Pennsylvania Hospital will celebrate its 275th anniversary by transforming its original location, the Pine Building, into a museum, which is scheduled to open to the public on May 8.
The project will join the America250 program of events marking the country’s semiquincentennial anniversary this summer.
“I am so excited to present this to the public in a way that it’s never been presented before,” said Stacey Peeples, curator and lead archivist at the Pine Building. “I want people to flood in here. I want it to be a good experience for Philadelphia. And I think it will be. I think there’s so much to offer.”

Pennsylvania Hospital, now part of the Penn Medicine network, was founded in 1751 “for the reception and cure of poor sick persons…free of charge.”
Museum visitors will be able to sit in the original surgical theater, where doctors performed amputations and other operations before live audiences, only some of them medical students. The patients were often conscious or plied with alcohol for the pain as anesthesia wasn’t invented until the 1840s.
People can also tour the medical library, which has a collection of more than 13,000 written volumes and texts dating back to the 15th century.

Archivists and historians are also restoring what was the original apothecary, which stored medicinal herbs, minerals and other substances used in treatments. The exhibit will show how therapies have advanced over time, leading up to today’s discoveries like CAR-T immunotherapy.
“So, you go from this idea of, we’re taking plants and we’re boiling down the root and everything, to this idea of, we’re using your own cells and your body to make you well,” Peeples said. “I think it’s really interesting to kind of look at that and say like, ‘Wow.’”
Most importantly, Peeples said the exhibits and galleries will honor the lives of patients and staff who were once fixtures of the Pine Building. And not just the notable doctors or the board of managers, but the everyday brick layers, matrons, housekeepers, cooks and others who worked there in the late 18th and early 19th centuries.
Peeples’ team is relying on information contained in matron logs, or records kept by what would be a modern-day chief operating officer who detailed the daily activities and responsibilities of staff at the time.
“Yes, the stories of Thomas Bond and Ben Franklin and the managers, they’re super important and you wouldn’t have the Pennsylvania Hospital without them,” she said. “But equally if it weren’t for all of the people who every day show up and do a job, you still wouldn’t have the Pennsylvania Hospital.”

The museum will use a timed-entry ticket reservation system and offer guided tours at least twice a day, with other visitors welcomed to explore on their own.
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