A late night talk show during happy hour at the Grape Room

Brandon Wetherbee’s plans for his live talk show at the Grape Room in Manayunk this Saturday night are quite simple – see how far he can go on stage without getting banned from returning to the venue in the future.

“It’s not the best idea, but at the end of the day let’s just have a drink and we’ll be fine,” Wetherbee says. “There’s no agenda besides having a good time. I’m not going to censor anybody.”

Saturday night’s 6 p.m. performance at the Grape Room marks the Philadelphia debut of “You, Me, Them, Everybody,” Wetherbee’s live talk show that is named after the podcast he has produced for four years. Local comedians Doogie Horner and Carolyn Busa will sit down for an interview segment with Wetherbee, who cites the thorough yet conversational approach of Terry Gross and Craig Ferguson’s charm and spontaneity as the main influences.

Wetherbee says his interview-centered talk show and podcast is the amalgamation of his previous creative projects within the past decade – which include playing in several Chicago punk bands, editing his own independent magazine, and writing arts and entertainment columns.

Saturday night’s guests are both hosts for their respective comedy shows, with Doogie Horner presiding over the monthly Ministry of Secret Jokes at Fergie’s Pub, and Carolyn Busa leading the Laughs on Fairmount open mic night every Monday at the Urban Saloon.

“It’s is kind of nerve wrecking because when I do stand-up…I don’t have to explain why I love owls or had a dream about Shaq,” Busa says of her past experiences being interviewed in front of an audience. “I couldn’t just run back to the bar or back to my car.”

Each live performance of “You, Me, Them, Everybody” stands apart from those before it because it follows no strict format, Wetherbee says – and that’s exactly how he prefers it.

“It’s like when you see Wilco and you don’t know whether they’re going to have a horn section or not, but you’ll hear most of the same songs,” Wetherbee says.

Since relocating from his native city of Chicago to Washington, DC last year, Wetherbee wants to expand his talk show to new venues throughout with East Coast with a fresh sense of urgency.

“There’s a small time frame for me to do this where it’s not creepy sad,” he says. “There’s no school of talk show hosts. When it’s entertainment based, you have try to keep plugging away.”