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The Centers for the Disease Control and Prevention found opioids played a role in nearly 48,000 deaths in the U.S. in 2017.

The appeal Tuesday challenges Judge Steven O'Neill's view that the women's testimony showed "chilling similarities" and pointed to a "signature" crime.

Pennsylvania Auditor General Eugene DePasquale is telling fellow Democrats that he's going to run for Congress in a Harrisburg-area district that's in Republican hands.

Philadelphia, state and federal officials gathered Tuesday to assure city residents Friday’s explosion and fire did not result in any public health threat.

Six months in, opponents say a smoking ban at Philadelphia inpatient addiction treatment centers is a barrier to getting started for some. Others leave early.

It wasn’t immediately known why the men were on the landing or why the fire escape collapsed.

The Delaware General Assembly approved Gov. John Carney’s $4.45 billion operating budget that includes new spending on education, social services and state workers.

Pa. GOP Chairman Val DiGiorgio resigned Tuesday, hours after the Inquirer published details of lewd text messages he allegedly exchanged with a City Council candidate.

Pennsylvania House Republicans have started moving the main spending bill for next year's state budget, and it seems likely the Senate and Governor Tom Wolf will support it.

The PPD is rolling out a new policy, which will be one of the most progressive in the country, on how officers interact with transgender and nonbinary people.

Philadelphia officials are trying a new approach to aggressive panhandling and interacting with people experiencing homelessness in general.

Ed Hipp is gearing up to sell his turkey bacon in local Walmart stores.

Thanks to Savannah Shepherd, a new historical marker memorializes the only documented lynching in Delaware.

SEPTA makes “the economic case” for fighting congestion with increased parking enforcement and other measures.

A hydrogen fluoride release could have had deadly consequences.