Police had to round up some puppies after the van that was transporting them hit a truck on the Pennsylvania Turnpike in Montgomery County.
The crash happened around 4:30 a.m. Wednesday in the eastbound lanes between Willow Grove and Bensalem.
Police tell KYW-TV the impact caused several of the dogs to get out of their cages.
The eastbound lanes were closed while authorities rounded up the puppies.
Two people were taken to a hospital. Their conditions are not known.
It is not known if any of the puppies were injured.